Archiv der Kategorie ‘Allergy‘

BPA, Found in Soup Can Lining, Associated with Adverse Health Effects in Humans

Consuming Canned Soup Linked to Greatly Elevated Levels of the Chemical BPA

A new study from researchers at the Harvard School of Public Health (HSPH) has found that a group of volunteers who consumed a serving of canned soup each day for five days had a more than 1,000% increase in urinary bisphenol A (BPA) concentrations compared with when the same individuals consumed fresh soup daily for five days. The study is one of the first to quantify BPA levels in humans after ingestion of canned foods.

The findings were published online November 22, 2011, in the Journal of the American Medical Association (JAMA) and will appear in the November 23/30 print issue.

“Previous studies have linked elevated BPA levels with adverse health effects. The next step was to figure out how people are getting exposed to BPA. We’ve known for a while that drinking beverages that have been stored in certain hard plastics can increase the amount of BPA in your body. This study suggests that canned foods may be an even greater concern, especially given their wide use,” said Jenny Carwile, a doctoral student in the Department of Epidemiology at HSPH and lead author of the study.

Exposure to the endocrine-disrupting chemical BPA, used in the lining of metal food and beverage cans, has been shown to interfere with reproductive development in animals and has been linked with cardiovascular disease, diabetes, and obesity in humans. In addition to the lining of food and beverage cans, BPA is also found in polycarbonate bottles (identified by the recycling number 7) and dentistry composites and sealants.

The researchers, led by Carwile and Karin Michels, associate professor in the Department of Epidemiology, set out to quantify whether canned-soup consumption would increase urinary BPA concentrations relative to eating fresh soup.

They recruited student and staff volunteers from HSPH. One group consumed a 12-ounce serving of vegetarian canned soup each day for five days; another group consumed 12 ounces of vegetarian fresh soup (prepared without canned ingredients) daily for five days. After a two-day “washout” period, the groups reversed their assignments.

Urine samples of the 75 volunteers taken during the testing showed that consumption of a serving of canned soup daily was associated with a 1,221% increase in BPA compared to levels in urine collected after consumption of fresh soup.

The researchers note that the elevation in urinary BPA concentrations may be temporary and that further research is needed to quantify its duration.

“The magnitude of the rise in urinary BPA we observed after just one serving of soup was unexpected and may be of concern among individuals who regularly consume foods from cans or drink several canned beverages daily. It may be advisable for manufacturers to consider eliminating BPA from can linings,” said Michels, senior author of the study.

Support for this study was provided by an Allen Foundation grant and a Training Grant in Environmental Epidemiology from the National Institute of Environmental Health Sciences.


Jenny L. Carwile, Xiaoyun Ye, Xiaoliu Zhou, Anotonia M. Calafat, Karin B. Michels, “Canned Soup Consumption and Urinary Bishphenol A: A Randomized Crossover Trial,”JAMA, online Nov. 22, 2011; in Nov. 23/30 print issue.

Video Channel:  Harvard School of Public Health

Twitter: Harvard School of Public Health

Prof. Doris Rapp – An icon of environmental medicine visits Germany

Evidence for the causes of environmental diseases have been around for a long time

The doctor and scientist Doris Rapp is one of those who not only practice environmental medicine, but has also made environmental medicine the most important thing in her life. The American spent two weeks in Germany. The reunion with Prof. Rapp was very productive and we were lucky enough to spend a beautiful day on the Moselle. Here is a small summary.

Researcher documented environmental disease

I met Prof. Rapp for the first time at a congress in Bad Emstal about 18 years ago. It was a crucial experience. In her presentation, she showed a video about a teacher who became ill from contaminated carpeting in the school. The teacher was filmed during a reaction to contaminated dust from the carpet. This video vividly conveys to the viewer what MCS is and what a reaction can look like. At that time I was at the very beginning of my own illness and had had similar reactions to certain pesticides. The teacher experienced convulsions and fell unconscious. I thought “my goodness, that’s me, that’s exactly like me, that’s what you have…“ After the lecture I spoke with Prof. Rapp and that was the beginning of an ongoing exchange of information and an interesting friendship. We met again at conferences in Germany, Holland and in the U.S., visited each other in Germany and the United States and exchanged e-mails. When I visited her in Scottsdale, she showed me one of her video archives. She had stored thousands of videos of children whom she had treated. They showed the patients during and after therapy and during testing of foods, mold, pollen, dust mites or chemicals. They displayed impressive evidence that can remove any last doubts as to the existence of environmental illnesses and allergies.

We can no longer ignore environmental illnesses

Dr. Binz and his wife invited the environmental doctor for this most recent visit to Germany. We had actually arranged to meet for a trip along the Moselle, which would start before lunch. We had a warm reunion and before we knew it we had already exchanged information and ideas and were in the midst of planning for future projects.

“I’m over 80 years old now and have no children, I don’t really need to be doing all this and I could be enjoying my peace at this age, but I see what’s going on, and I simply cannot remain silent. We have so many chemicals in our environment, in the food we eat, in the water we drink and the air that we are constantly breathing. They affect each of our body systems and we can no longer ignore this. Almost every second person in my country has cancer and that is just not acceptable”, says Doris Rapp.

“The politicians and the public must realize the impact the flood of chemicals has on us and no one should keep insisting that we do not know where all the increasing diseases that occur are coming from. The evidence is there. We have animal testing to prove it. That’s why, as a doctor, I ask: How much more has to happen before we admit to the real causes? I won’t accept hearing when one says, “Yes, but there’s nothing we can do about it.” Yes, there is, because you can educate yourself and there’s a hell of a lot you can do,” says Prof Rapp, who is enraged about the current situation.

Solutions are often very simple

Prof. Rapp is no one who can be at odds with the world and ignore the solutions. She is in the process of writing another book. “It will be a small book, only 30 pages. Every reader can easily understand how he/she can shape his environment in order to stay healthy. The tips in this book will not cost anyone a fortune, they can easily be implemented without major expense. It will help anyone who wants to change something and wants to improve his health. The doctor cites two examples:

“Many people react to foods, but are not sure towards which foods. Expensive tests are not necessary. I advise people to think about what they eat most, foods that they downright crave. Experience has shown that these are the foods that are eaten every day and most likely those which cause reactions. The solution: omit the suspected food for a week. You can test one food after another. This costs nothing! ”

“Some people live in a house that is contaminated with pollutants or contaminated by mold. My experience is that five out of seven people can improve their health by 70% if they obtain a high quality air purifier that is capable of filtering hundreds of chemicals from the air in your home. Such an air purifier may cost a bit, but I have often seen patients who got better over night. So it’s worth it if you are unable to directly move out of the apartment or house.”

The new book will be published this year, and Professor Rapp has authorized me to translate it into German. She also gave me permission to translate videos and other books into our language, contributing knowledge to allergy sufferers and chemically sensitive people in the German-speaking countries, helping them to find a way back into life.


A trip along the Moselle

During the drive to the historic Moselle wine village, Bernkastel, to Traben-Trabach and the drive back to Trier, Prof. Rapp was bursting with innovative ideas that we will begin to put into action in the next few months and they will benefit the environmentally ill in many ways.

Author: Silvia K. Müller, CSN – Chemical Sensitivity Network, 12 September 2011

PureNature Online Shop now available in Spain

Since July 8th, 2011, we are pleased to welcome an online PureNature shop in Spain. Spanish customers will find over 2,000 products that will help them to live more comfortably with their allergies and to assist them with more environmentally conscious living.

A customer on-site service director has been operating since last year. Our representative, Mr. David Palma has replied to the Spanish customer inquiries with great expertise and is in constant contact with his German colleagues in order to satisfy all customer requests and inquiries with the greatest customer satisfaction.

The translation of the PureNature products took many months to complete and is ongoing. The effort has paid off, because with the launch of the online store, it is now much easier for the Spanish customers to shop. The goods are shipped from the PureNature, based in Idar-Oberstein, Germany to Spain. The new customers are welcomed by receiving free shipping during the month of July with their first order.

A warm welcome to Spain, and at this point, a big thank you to David Palma and his wife Eva Caballé, without whom this project would never have become a reality!

All the best,

from the entire PureNature team


Have a look at the new Spanish PureNature Shop:


Guidelines to improve employee health

Employer demands: No perfume, no cookies, no soda, no French fries…

The staff at the New York Health Department must make fundamental changes. The new service manual, titled “Life in the Cubicle Village” requires drastic changes in many parts of the workplace. Employees are discouraged in using perfume and scented body care products, and are encouraged to change their eating habits in the workplace. The New York City Health Department wants to set a good example and be a role model to the other people in the city. Refraining from eating cookies and consuming fried food is now enforced under the new guidelines. Not all employees like these new changes, but these changes are useful if one looks seriously at the goal of being a role model to others, initiated by this employer.

Bureau represents personal health interests

The New York Department of Health has prevailed in the past to improve the health of its city inhabitants, which at times has caused a stir. Initially, the general smoking ban on the beaches in the region was a difficult transition, as was the prohibition of the use of hydrogenated cooking oil in fast food restaurants in the city.

With the new guidelines, the health department clarifies that these prohibitions are designed to seriously improve the health of the population. Not all employees are happy about the changes in the manual and some perceive them as intolerable harassment, and are not pleased with the threatening fine for non-compliance. Others are happy and have recognized that the health and well being of all employees will be enhanced by the reforms.

Employer demands employees to omit fragrances and perfume

“Spreading odors is just like noise spreading beyond the walls in the cubicle,” explained the York Board of Health. Their employees need the knowledge that it is important to refrain from fragrances and to refrain from dispensing of perfume because some people are very sensitive and react to the chemicals in perfume, cologne and other perfumed products. Therefore employees are being asked to maintain good personal hygiene without using products with noticeable fragrance or odor.

No detergent, disinfectant, or room scents allowed

Because many commercially available cleaning agents and disinfectants contain chemicals harmful to health, the health department requires that employees leave such products at home and not bring them to the workplace. If an employee needs a cleaning agent, he may apply to the cleaning service which has available products satisfying the required safety standards. “Air freshener” or room sprays, because of their ingredients, which can harm the health of others, are prohibited in the workplace of the Cubicle Village as well.

Healthy diet instead of sweet and greasy

French fries at meetings, events, or at the employee birthday parties? A “No Go” at the New York Department of Health. Fried food is not allowed. If a cake is brought to the party, then no cookies are allowed. Instead, whole-grain crackers are served. The preferred drink is filtered water because it is healthier and avoids high calories. If an employee or his colleague still wants to offer something different, the drink should not exceed 25 calories per pint. Filtered water must still be on the table. These provisions are designed to protect health and the environment.

Bureau will practice what they preach

The New York Health Department’s colored booklet with new operating procedures may not set so well with some employees, but on the other hand, the department actually requires no more from the employees than what they themselves will practice. They will practice what they preach in order to improve the health of people in New York. One goal is to cut obesity, reduce heart disease by cutting down on the fats and salty foods, cut down on allergies, asthma and other diseases that are common in the population which can be caused by unhealthy lifestyles. Their new guidelines will promote healthy lifestyles instead.

To simply preach to New Yorkers, to be free of salty, greasy fast food, alcohol, cigarettes, sweets and to avoid donuts is not enough. Will those in charge continue to consume these items? To ban soft drinks in schools, at festivals, and in staff offices while those making the guidelines still continue to use these? A true role model would in fact also refrain from the items they are asking their employees to refrain from. That is the commitment which those in charge have made to their employees.

After two or three years, the Department of Health will be able to prove that the new guidelines are actually not arbitrary harassment, but are measures that serve the health of the people. It is expected that the causes of absenteeism of around 3,000 employees, and leaving the profession due to illness and deaths from degenerative diseases will be reduced. Such figures could provide the health department the black and white proof needed for New Yorkers, that a healthy lifestyle, a good diet, and refraining from chemical products can have a positive impact.

Author: Silvia K. Müller, CSN – Chemical Sensitivity Network, June 2011

Strict avoidance – the best way to treat and prevent food allergies?

Identification of biomarkers is needed for patients who react to food

In a recent study, scientists identified a prestigious American university asking if strict allergen avoidance is the most appropriate strategy for dealing with food allergies. Traditionally, avoiding the foods which one cannot tolerate has been a standard treatment for allergies to food. This advice is based on the assumption that contact can lead to an allergic reaction and avoidance accelerates the recovery. Recent studies make this assumption.

Heat largely kills allergens

Recent studies show that most children with a milk allergy tolerate eggs and similar foods when they were hot. In addition, clinical studies show that eating tiny amounts of food could result in desensitization. It must be noted at this point that this procedure can be naturally carried out in the presence of a physician or an at an allergy clinic when a child suffers from severe allergic reactions.

Late introduction of allergens offers no advantage

Recently published epidemiological studies do not support the previous assumption that a delayed introduction of highly allergenic foods for infants and young children prevents food allergies. In fact, the recent data suggest that delaying the introduction of certain foods may even increase the risk of developing an allergy.

Biomarkers could provide a better understanding

The latest data suggest that strict allergen avoidance as a treatment is not always necessary. Exposure to a particular food can even be a therapeutic measure. An extended delay in the introduction of food allergens in the diet of young children may increase the risk of allergies as shared by scientists in their report. In many cases, the strict avoidance of a treatment is clearly necessary, however, so the scientists at the Mount Sinai Hospital continue to state, that further studies are needed to assess risks and benefits of exposure to allergens in more detail. They agree that the identification of biomarkers is needed for patients who react to food.

Author: Silvia K. Müller, CSN – Chemical Sensitivity Network


Kim JS, Safe S., Should there be strict avoidance of foods in prevention and treatment of food allergy?, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, New York, USA, Curr Opin Allergy Clin Immunol. February 16th, 2010.

Allergies caused by cuddly animals

An early determination of whether a child is sensitized to inhaled allergens such as pollen, mold or dust mites, serves as an important prognostic factor. Unfortunately, the diagnosis of small children is quite difficult to perform. Scientists from Belgium found that stuffed animals have an influence on the development of allergies in children.

Testing to identify allergies

A Belgian team of scientists tried, through a study of infants aged 0 to 2 years, to determine whether the allergies of children are based on a relation to environmental influences, or based on whether one has a family history of allergies. For this purpose, 824 infants who were previously tests with skin tests, inhaled allergens, and foods in an asthma clinic, were examined by the medical profession.

Stuffed animals make for allergies

It was determined that 40% of young children could be allergic. 28% responded to the respiratory allergens such as house dust, pollen and molds. For most young children dust mite allergens were the worst.

What the scientists also discovered is astonishing

Among children who slept with stuffed animals in bed, allergies were much more pronounced than in children who took no soft animals to bed. Factors such as gender, residence in a nursery, or eczema did not matter in the development of allergy, according to the doctors.

Sacrifice not necessary

Children love their stuffed animals, and they give them security. To take them away does not make sense. To make sure a stuffed animal does not lead to allergies, one should purchase a stuffed animal free of pollutants. Some manufacturers have already attempted to make them free of chemicals and other irritating substances. As a further preventive measure, only one stuffed animal should be taken to bed. It is also important for allergy prevention, to remember to wash soft toys regularly.

Author: Silvia K. Müller, CSN – Chemical Sensitivity Network


Image de Erling G, Mathot M, Agustsson S, Tuerlinckx D, Jamart J, Bodart E. Early skin sensitization to aero-allergens, Clin Exp Allergy. 2008 Apr; 38 (4) :643-8.

Medicine: Causes of nasal polyps discovered

Heredity, allergies, environmental factors, and chemicals on the job

The cause of polyps in the nose has been long regarded as a largely unknown. Children, like adults, may be affected from these benign growths in the nose, making it difficult to breathe and may also lead to significant physical impairments.

The size of the growths vary, ranging from millimeters to a larger size which makes breathing through the nose almost impossible. Previously suspected triggers were chronic inflammation caused by viruses, bacteria or fungi, plus allergies and asthma.

A team of scientists from Greece did a case-control study which revealed further clues and uncovered other causes. Environmental factors and chemicals at work had a considerable significance for the occurrence of polyps.

Study reveals causes of polyps

A Greek research team studied 100 patients from three Athens hospitals and 102 control subjects. The following factors were considered for each study participant: the gender, education level, family history, allergies, smoking, occupational activities and environmental impacts.

Symptoms of nasal polyps

The symptoms caused by nasal polyps depends on the severity and the anatomical features.

The following symptoms are commonly observed:

  • Difficult breathing through the nose
  • Vague, slurred pronunciation, speaking through his nose,
  • poor performance
  • sleep disorders, snoring
  • Decreased sense of smell
  • Frequent inflammation of the sinuses

Inheritance and allergy causes of polyps in the nose

The researchers found that polyps can also be inherited. A total of 13.3% of the patients inherited the polyps. In the control group, however, none of the family members had nasal polyps. The presence of allergies was higher in patients with polyps. In 64% of the patients, different allergies were found, and in 12% there was a probable presence of allergies.

Environmental factors and chemical causes for polyps

In some workplaces, employees experience heavy contact with chemicals and dust. This may also lead to nasal polyps, the researchers found. In particular, exposure to chemicals at work turned out to be a common cause in the patients with polyps. Smoking, however, was not a significant trigger factor; and in addition, the level of education was also irrelevant for the occurrence of polyps.

The scientists concluded from their study results that nasal polyps are often caused by allergies and may be familial. A genetic predisposition is a cause for consideration by the Greek scientists, but also the influence and incidence of chemicals and substances from the environment and the workplace can cause nasal polyps. Patients had more polyps, when confronted with chemicals in the workplace, than when polyps occurred in the family.

Treatment of nasal polyps

The treatment of choice for nasal polyps was previously two options: Long-term treatment with cortisone spray (usually at least 6 months) and / or surgery. The findings of the scientists from Athens however suggest another approach: allergen avoidance, and exposure and eliminating the chemicals in the living and working environment. Where allergens and chemicals cannot be avoided, wearing protective masks with good ventilation would be a good preventive measure of protection to prevent exposures to chemicals and dust.

Autor: Silvia K. Müller, CSN – Chemical Sensitivity Network


Alexiou A, Sourtzi P, Dimakopoulou K, Manolis E, Velonakis E., Nasal polyps: heredity, allergies, and environmental and occupational exposure, J Otolaryngol Head Neck Surg. 2011 Feb;40 (1):58-63.

Use of hair dye chemicals can affect the immune system

Hair dyes are involved in the development of autoimmune diseases and cancer

The first gray hairs indicate our aging and many have only one thought: The gray hairs must disappear. There are many hair dyes on the market, but most contain questionable chemicals to produce their coloring effect. Recently scientists at the University of Copenhagen showed that commercial -p-phenylenediamine (PPD)-contained in the hair dye composition is a potent activator on the immune system. When animal models were in contact with PPD, severe hypersensitivity reactions resulted.

With the discovery of these research scientists, the result leaves only two alternatives to consider: either accept the gray hair, or resort to a harmless lichen hair dye with active ingredients from plants.

Why doesn’t everyone react to the chemicals in hair color products?

With their new study, scientists from Copenhagen wanted to find out why only a minority of the population suffers with hypersensitivity to permanent hair dyes. The scientific research team found that the majority of people are indeed sensitized to hair dyes or the rest of the users develop an immunological tolerance.

Consumer tests simulated situation

To investigate whether an immune response takes place, the researchers exposed mice repeatedly to PPD-containing hair dyes in a manner as it is exposed to the consumer in a similar way. For this purpose, a commercial hair dye that contains PPD, was tested on animals. The local immune response was evaluated by ear swelling and by histological examinations. The immune response in the lymph nodes was analyzed by the researchers using flow cytometry, a still relatively new laboratory technique.

Inflammation and swelling worsened by repeated contact

Hair dye caused local inflammation, which was determined by swelling and cell infiltration of the treated ears. In addition, contact with the hair dye caused T-cell activation, as evidenced by the T-cell proliferation and the production of IFN gamma and IL-17 which was detected in the lymph nodes. The inflammatory reaction was at its peak after the fourth contact with the hair dye.

Effects observed on the immune system

From that point on, the team of scientists observed an up-regulation of regulatory T cells and IL-10 producing cells. The study thus shows that PPD-containing hair dyes strongly influence the immune system. In addition, it became clear that they are potent skin sensitizers that activate the inflammatory T-cells and to induce PPD-containing hair dyes and anti-inflammatory mechanisms. This may explain why many consumers using hair dye can be use the dyes repeatedly without significant development of allergies. Scientists from Denmark, however, believe that one cannot feel entirely safe doing this because facts have been raised concerning the question of whether the influence of the immune modulatory effects of hair dyes are involved in the development of autoimmune diseases and cancer.

Author: Silvia K. Müller, CSN – Chemical Sensitivity Network


Rubin IM, Dabelsteen S, Nielsen MM, White IR, Johansen JD, Geisler C, Bonefeld CM., Repeated exposure to hair dye induces regulatory T cells in mice, Department of International Health, Immunology and Microbiology, University of Copenhagen, Denmark, Br J Dermatol., May 13, 2010.

Allergists warn to pay attention to the drug allergies

One in every three drug-allergy patients, takes the medicine again

Drugs can not only relieve symptoms but can also cause them. More than seven percent of the population suffers from a drug incompatibility, many of which are allergic problems. Common triggers of drug allergies are penicillin and other antibiotics. Painkillers like aspirin (acetylsalicylic acid) are the cause of urticaria, shock, or asthma. The allergist, Professor Thomas Fuchs, and his team at the Dermatology University Medical Clinic at Goettingen stated in a recent study that drug allergies may have long term risks. “Every third patient, a year after diagnosis, will take a drug with the allergic trigger. Patients with allergies to drugs will forget or ignore the recommendations of their allergists over time. It is frightening that even doctors ignore our recommendations and prescribe the allergic triggers,” criticizes Fuchs. The consequences can be severe, and in the worst case, a reaction can threaten and endanger life.

Fuchs interviewed 80 patients with allergies to non-steroidal painkillers such as aspirin, paracetamol, diclofenac, or ibuprofen. He spoke with them regarding their experiences a few years after diagnosis. Forty-one percent had taken the painkillers despite the known allergy-causing effects of the drug. The most common causes for taking the allergy causing drugs again were that the people knew about the allergens or safe alternatives, but after a few years, or as they were no longer taking any medication, they forgot to check the informational leaflet for possible reactive ingredients. In some cases even doctors prescribed a drug with the allergic trigger. Also several patients were deliberately triggering a medicine allergy just out of curiosity to see if a reaction would occur again.

The skin clinic at Goettingen demonstrated the importance of intensive education for people with drug allergies. According to Fuchs, the person should meet with their allergist again a year after the original diagnosis. He also advises patients to always carry an allergy “passport”. In this “passport” the drug trigger(s) is/are recorded so that any attending doctors can immediately recognize which medicines can cause dangerous reactions. “People with a drug allergy should inform their doctors as well, to ensure is that no medication is prescribed with those reactive allergens,” the allergy specialist Thomas Fuchs recommended at the Skin Clinic of Goettingen.

Author: Association of German Allergists Association (AEDA)


Buhl T, Meynberg HC, Kaune KM, Hünecke P, Schoenberg MP, Fuchs D, Long-term follow-up of patients with hypersensitivity to nonsteroidal anti-inflammatory drugs reveals shortcomings in compliance and care, J Allergy Clin Immunol 2011: 127 (1): 284-285

Gluten-free diet reduces bone problems in children with celiac disease

Celiac disease is a congenital intestinal disorder that is characterized by a lifelong intolerance to the ingestion of gluten. Gluten is a protein found in wheat, rye and barley. Celiac illness can occur at any age, but most of the intolerance occurs during early childhood (between the 9th and 24th month of life). Frequently, people who suffer from celiac problems have a decrease in bone density. A current article published in the medical journal, Nutrition Reviews, has reviewed the existing literature on the subject and revealed that a gluten-free diet can strongly influence recovery in children.

Celiac disease can reduce bone density

Metabolic bone disease is among the most significant and frequent complication of celiac disease. Decreased bone mineral density in children can lead to the fact that they are not in a position to develop optimal bone mass and bone loss in adulthood. Both increase the risk of developing, osteoporosis. People with celiac disease, also run an additional risk of bone fractures.

Gluten-free diet can lead to recovery

However, there is evidence that a gluten-free diet can promote an increase of bone density quickly. This can lead to complete recovery of bone mineralization in children. A gluten-free diet improves bone mineral density in adults, but normalization is rare. Children can get normal bone mass if the diagnosis and treatment were carried out before puberty. This also prevents the development of osteoporosis in later life.

Moreover, nutrients which contain calcium and vitamin D seem to improve bone mineral density in children and adults who suffer from celiac disease.


“Our findings reinforce the importance of a strict gluten-free diet, which currently appears to be the only scientifically proven treatment for celiac disease,” said the study authors. “Early diagnosis and treatment are crucial to complications from celiac disease, such as preventing reduced bone density.”

Literature: Wiley-Blackwell, gluten-free diet Reduces bone problems in children with celiac disease, October 8, 2009